Clinical Development of Regenerative Medicine Targeted for Intervertebral Disc Disease

被引：29
作者：
Sakai, Daisuke [1 ]
Schol, Jordy [1 ]
Watanabe, Masahiko [1 ]
机构：
[1] Tokai Univ, Sch Med, Surg Sci, Dept Orthopaed Surg, Isehara, Kanagawa 2591193, Japan
来源：
MEDICINA-LITHUANIA | 2022年 / 58卷 / 02期
关键词：
cell therapy; stem cells; intervertebral disc; degeneration; spine; low back pain; regeneration; clinical trials; minimally invasive surgery; LOW-BACK-PAIN; MESENCHYMAL STEM-CELLS; LUMBAR SPINE SURGERY; BONE-MARROW-CELLS; CHONDROCYTE TRANSPLANTATION; STROMAL CELLS; REPAIR; DEGENERATION; EXPERIENCE; INJECTION;
D O I：
10.3390/medicina58020267
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Low back pain is critical health, social, and economic issue in modern societies. This disease is often associated with intervertebral disc degeneration; however, contemporary treatments are unable to target this underlying pathology to alleviate the pain symptoms. Cell therapy offers a promising novel therapeutic that, in theory, should be able to reduce low back pain through mitigating the degenerative disc environment. With the clinical development of cell therapeutics ongoing, this review aims to summarize reporting on the different clinical trials and assess the different regenerative strategies being undertaken to collectively obtain an impression on the potential safety and effectiveness of cell therapeutics against intervertebral disc-related diseases.
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页数：18
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