Water proton NMR-a sensitive probe for solute association

被引：32

作者：

Feng, Yue ^{[1
]}

Taraban, Marc B. ^{[1
]}

Yu, Yihua Bruce ^{[1
]}

机构：

[1] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 31期

关键词：

NUCLEAR MAGNETIC-RESONANCE; SODIUM CAPRYLATE SOLUTIONS; RELAXATION; SUSCEPTIBILITY; PROTEINS; TEMPERATURES; MECHANISM; QUALITY;

D O I：

10.1039/c5cc00741k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It is found that the transverse relaxation rate R-2 of the water protons can be used to quantify protein aggregation and surfactant micellization in water. The simplicity and high intensity of the water proton signal enables non-invasive chemical analysis not readily achievable through solute proton signals, such as inspecting finished biologic products.

引用

页码：6804 / 6807

页数：4

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