A microwave-enhanced, solventless Mannich condensation of terminal alkynes and secondary amines with para-formaldehyde on cuprous iodide doped alumina

被引：40

作者：

Kabalka, GW ^{[1
]}

Zhou, LL

Wang, L

Pagni, RM

机构：

[1] Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA

[2] Univ Tennessee, Dept Radiol, Knoxville, TN 37996 USA

来源：

TETRAHEDRON | 2006年 / 62卷 / 05期

关键词：

cuprous salts; Mannich reaction; solventles; microwave;

D O I：

10.1016/j.tet.2005.10.049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A microwave-enhanced, solventless Mannich condensation of terminal alkynes and secondary amines with para-formaidehyde on cuprous iodide doped alumina has been developed. beta-Aminoalkynes are generated in good yields. The reaction can be extended to include a cyclization, which affords 2-substituted benzo[b]furans. The chemoselectivity of the reaction indicates that terminal alkynes are much more reactive than enolizable ketones under the reaction conditions. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：857 / 867

页数：11