Training and anti-CSPG combination therapy for spinal cord injury

被引：55

作者：

Garcia-Alias, Guillermo ^{[2
]}

Fawcett, James W. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Clin Neurosci, Cambridge Ctr Brain Repair, Cambridge CB2 0PY, England

[2] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA

来源：

EXPERIMENTAL NEUROLOGY | 2012年 / 235卷 / 01期

关键词：

Spinal cord injury; Plasticity; Rehabilitation; Inhibitory molecules; CENTRAL-NERVOUS-SYSTEM; CHONDROITIN SULFATE PROTEOGLYCAN; EXTRACELLULAR-MATRIX; FUNCTIONAL RECOVERY; PERINEURONAL NETS; AXONAL REGENERATION; GLIAL SCAR; SYNAPTIC PLASTICITY; REACTIVE ASTROCYTES; LOCOMOTOR RECOVERY;

D O I：

10.1016/j.expneurol.2011.09.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Combining different therapies is a promising strategy to promote spinal cord repair, by targeting axon plasticity and functional circuit reconnectivity. In particular, digestion of chondroitin sulphate proteoglycans at the site of the injury by the activity of the bacterial enzyme chondrotinase ABC, together with the development of intensive task specific motor rehabilitation has shown synergistic effects to promote behavioural recovery. This review describes the mechanisms by which chondroitinase ABC and motor rehabilitation promote neural plasticity and we discuss their additive and independent effects on promoting behavioural recovery. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：26 / 32

页数：7

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