HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β

被引：12
|
作者：
Tufa, Dejene M. [1 ]
Ahmad, Fareed [1 ]
Chatterjee, Debanjana [1 ]
Ahrenstorf, Gerrit [1 ]
Schmidt, Reinhold E. [1 ]
Jacobs, Roland [1 ]
机构：
[1] Hannover Med Sch MHH, Dept Clin Immunol & Rheumatol, Hannover, Germany
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 73卷 / 01期
关键词：
HIV; slanDCs; IL-1; beta; DENDRITIC CELLS; 6-SULFO LACNAC; TNF-ALPHA; NK CELLS; BLOOD; INTERLEUKIN-1; MACROPHAGES; POPULATION; ACTIVATION; DISEASE;
D O I：
10.1097/QAI.0000000000001082
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1 during HIV-1 infection as compared with healthy controls. IL-1 plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection.
引用
收藏
页码：34 / 38
页数：5
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