Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-β aggregation

被引：137

作者：

Thomas, T ^{[1
]}

Nadackal, TG ^{[1
]}

Thomas, K ^{[1
]}

机构：

[1] Woodlands Med Ctr & Endron Therapeut, Oldsmar, FL 34677 USA

来源：

NEUROREPORT | 2001年 / 12卷 / 15期

关键词：

Alzheimer's disease; amyloid-beta; amyloid aggregation; amyloid plaque; aspirin; COX-2; inhibitors; inflammation; neurotoxicity; NSAIDs;

D O I：

10.1097/00001756-200110290-00024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurotoxic and proinflammatory actions of the Alzheimer peptide amyloid-beta (A beta) are dependent on its aggregation and beta -sheet conformation. Chronic use of non-steroidal antiinflammatory drugs (NSAIDs) such as aspirin for arthritis decreases the risk of developing Alzheimer's disease (AD) by unknown mechanisms. We report that these drugs inhibit human A beta aggregation in vitro and reverse the beta -sheet conformation of preformed fibrils at clinically relevant doses. Aspirin prevented enhanced A beta aggregation by aluminum, an environmental risk factor for AD. This anti-aggregatory effect was restricted to NSAIDs and was not exhibited by other drugs used in AD therapy. NSAIDS may have a role in the prevention and treatment of AD, in addition to a number of age-related disorders such as arthritis, cardiovascular disease and cancer. NeuroReport 12:3263-3267 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：3263 / 3267

页数：5

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