Early Detection of Sporadic Pancreatic Cancer Summative Review

被引：216

作者：

Chari, Suresh T. ^{[1
]}

Kelly, Kimberly ^{[2
]}

Hollingsworth, Michael A. ^{[3
,4
]}

Thayer, Sarah P. ^{[5
]}

Ahlquist, David A. ^{[1
]}

Andersen, Dana K. ^{[6
]}

Batra, Surinder K. ^{[3
]}

Brentnall, Teresa A. ^{[7
]}

Canto, Marcia ^{[8
]}

Cleeter, Deborah F. ^{[9
]}

Firpo, Matthew A. ^{[10
]}

Gambhir, Sanjiv Sam ^{[11
]}

Go, Vay Liang W. ^{[12
]}

Hines, O. Joe ^{[13
]}

Kenner, Barbara J. ^{[14
]}

Klimstra, David S. ^{[15
]}

Lerch, Markus M. ^{[16
]}

Levy, Michael J. ^{[5
]}

Maitra, Anirban ^{[17
]}

Mulvihill, Sean J. ^{[10
]}

Petersen, Gloria M. ^{[18
]}

Rhim, Andrew D. ^{[19
,20
]}

Simeone, Diane M. ^{[21
]}

Srivastava, Sudhir ^{[22
]}

Tanaka, Masao ^{[23
,24
]}

Vinik, Aaron I. ^{[25
]}

Wong, David ^{[26
]}

机构：

[1] Mayo Clin, Dept Med, Rochester, MN USA

[2] Univ Virginia, Dept Biomed Engn, Charlottesville, VA USA

[3] Univ Nebraska, Fred & Pamela Buffett Canc Ctr, Dept Biochem & Mol Biol, Omaha, NE 68182 USA

[4] Univ Nebraska, Fred & Pamela Buffett Canc Ctr, Dept Pathol & Microbiol, Omaha, NE 68182 USA

[5] Univ Nebraska, Fred & Pamela Buffett Canc Ctr, Dept Surg, Omaha, NE 68182 USA

[6] NIDDK, Div Digest Dis & Nutr, NIH, Bethesda, MD 20892 USA

[7] Univ Washington, Div Gastroenterol, Seattle, WA 98195 USA

[8] Johns Hopkins Univ, Sch Med, Div Gastroenterol, Baltimore, MD USA

[9] Sawgrass Leadership Inst, Ponte Vedra Beach, FL USA

[10] Univ Utah, Dept Surg, Salt Lake City, UT USA

[11] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA

[12] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[13] Univ Calif Los Angeles, Gen Surg, Los Angeles, CA USA

[14] Kenner Family Res Fund, New York, NY 10075 USA

[15] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[16] Ernst Moritz Arndt Univ Greifswald, Dept Internal Med, Greifswald, Germany

[17] Univ Texas MD Anderson Canc Ctr, Div Pathol & Lab Med, Houston, TX 77030 USA

[18] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[19] Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA

[20] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[21] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI USA

[22] NCI, Canc Biomarkers Res Grp, Canc Prevent Div, Rockville, MD USA

[23] Kyushu Univ, Dept Surg, Fukuoka 812, Japan

[24] Kyushu Univ, Dept Oncol, Fukuoka 812, Japan

[25] Eastern Virginia Med Sch, Dept Med, Norfolk, VA 23501 USA

[26] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, CLA Sch Dent, Div Oral Biol & Med, Los Angeles, CA 90024 USA

来源：

PANCREAS | 2015年 / 44卷 / 05期

关键词：

biomarker; diabetes; screening; familial; imaging; pancreatic ductal adenocarcinoma;

D O I：

10.1097/MPA.0000000000000368

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving survival in PC. Addressing this urgent need, the Kenner Family Research Fund conducted the inaugural Early Detection of Sporadic Pancreatic Cancer Summit Conference in 2014 in conjunction with the 45th Anniversary Meeting of the American Pancreatic Association and Japan Pancreas Society. This seminal convening of international representatives from science, practice, and clinical research was designed to facilitate challenging interdisciplinary conversations to generate innovative ideas leading to the creation of a defined collaborative strategic pathway for the future of the field. An in-depth summary of current efforts in the field, analysis of gaps in specific areas of expertise, and challenges that exist in early detection is presented within distinct areas of inquiry: Case for Early Detection: Definitions, Detection, Survival, and Challenges; Biomarkers for Early Detection; Imaging; and Collaborative Studies. In addition, an overview of efforts in familial PC is presented in an addendum to this article. It is clear from the summit deliberations that only strategically designed collaboration among investigators, institutions, and funders will lead to significant progress in early detection of sporadic PC.

引用

页码：693 / 712

页数：20