CD4-CD8 differentiation in the thymus: connecting circuits and building memories

被引：45

作者：

Xiong, Yumei ^{[1
]}

Bosselut, Remy ^{[1
]}

机构：

[1] NCI, Lab Immune Cell Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 02期

关键词：

T-CELL LINEAGE; TRANSCRIPTION FACTORS; GENE-EXPRESSION; CD4; EXPRESSION; THYMOCYTE DIFFERENTIATION; RUNX PROTEINS; THPOK; COMMITMENT; ACTIVATION; RECEPTOR;

D O I：

10.1016/j.coi.2012.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The proper choice of the CD4-helper or CD8-cytotoxic lineages by developing T cells is crucial for the generation of an antigen-responsive and functionally fit T cell repertoire. Here we present a brief overview of the transcr ptional control of this process, with emphasis on two issues. The study of Cd4 expression, that had previously generated important paradigms for transcriptional regulation in eukaryotic cells, now brings new twists to the concept of 'epigenetic memory'. And connections are emerging between transcriptional regulators critical for commitment to either lineage. The present review attempts to integrate these findings and d scusses the still elusive mechanisms that match CD4-CD8 lineage differentiation to MHC specificity.

引用

页码：139 / 145

页数：7

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