Selective reduction of IFN-γ single positive mycobacteria-specific CD4+T cells in HIV-1 infected individuals with latent tuberculosis infection

被引：17

作者：

Riou, Catherine ^{[1
,2
]}

Bunjun, Rubina ^{[1
]}

Muller, Tracey L. ^{[1
]}

Kiravu, Agano ^{[1
]}

Ginbot, Zekarias ^{[1
]}

Oni, Tolu ^{[2
,3
,4
]}

Goliath, Rene ^{[2
,3
]}

Wilkinson, Robert J. ^{[2
,3
,5
,6
]}

Burgers, Wendy A. ^{[1
,2
]}

机构：

[1] Univ Cape Town, Div Med Virol, Dept Pathol, Cape Town, South Africa

[2] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa

[3] Univ Cape Town, Inst Infect Dis & Mol Med, Clin Infect Dis Res Initiat, Cape Town, South Africa

[4] Univ Cape Town, Sch Publ Hlth & Family Med, Div Publ Hlth Med, Cape Town, South Africa

[5] Francis Crick Inst, Mill Hill Lab, London, England

[6] Imperial Coll London, Dept Med, London, England

来源：

TUBERCULOSIS | 2016年 / 101卷

基金：

英国医学研究理事会; 新加坡国家研究基金会; 英国惠康基金; 美国国家卫生研究院;

关键词：

HIV; Mycobacterium tuberculosis; LTBI; PPD; BCG; ESAT-6/CFP-10; Polyfunction; Memory; HIV-1; INFECTION; T-CELLS; DEPLETION;

D O I：

10.1016/j.tube.2016.07.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-1 is recognized to increase the risk for tuberculosis even before CD4+ T cell deficiency is profound. To better understand how HIV-1 alters immunity to latent tuberculosis, we compared the magnitude and functional profile of mycobacteria-specific CD4+ T cells between HIV-uninfected and HIV-infected individuals, using flow cytometry. In HIV-1 infection, IFN-gamma single positive mycobacteria-specific CD4+ T cells were decreased, while the frequency of polyfunctional cells (IFN-gamma+IL-2+TNF-alpha+) remained unchanged. Moreover, the proportion of IFN-gamma single positive cells correlated inversely with viral replication. Our results suggest that HIV-1 affects mycobacteria-specific cells differentially, depending on their functional capacity. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：25 / 30

页数：6

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