Selective reduction of IFN-γ single positive mycobacteria-specific CD4+T cells in HIV-1 infected individuals with latent tuberculosis infection

被引：17
|
作者：
Riou, Catherine [1 ,2 ]
Bunjun, Rubina [1 ]
Muller, Tracey L. [1 ]
Kiravu, Agano [1 ]
Ginbot, Zekarias [1 ]
Oni, Tolu [2 ,3 ,4 ]
Goliath, Rene [2 ,3 ]
Wilkinson, Robert J. [2 ,3 ,5 ,6 ]
Burgers, Wendy A. [1 ,2 ]
机构：
[1] Univ Cape Town, Div Med Virol, Dept Pathol, Cape Town, South Africa
[2] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa
[3] Univ Cape Town, Inst Infect Dis & Mol Med, Clin Infect Dis Res Initiat, Cape Town, South Africa
[4] Univ Cape Town, Sch Publ Hlth & Family Med, Div Publ Hlth Med, Cape Town, South Africa
[5] Francis Crick Inst, Mill Hill Lab, London, England
[6] Imperial Coll London, Dept Med, London, England
来源：
TUBERCULOSIS | 2016年 / 101卷
基金：
英国医学研究理事会; 新加坡国家研究基金会; 英国惠康基金; 美国国家卫生研究院;
关键词：
HIV; Mycobacterium tuberculosis; LTBI; PPD; BCG; ESAT-6/CFP-10; Polyfunction; Memory; HIV-1; INFECTION; T-CELLS; DEPLETION;
D O I：
10.1016/j.tube.2016.07.018
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
HIV-1 is recognized to increase the risk for tuberculosis even before CD4+ T cell deficiency is profound. To better understand how HIV-1 alters immunity to latent tuberculosis, we compared the magnitude and functional profile of mycobacteria-specific CD4+ T cells between HIV-uninfected and HIV-infected individuals, using flow cytometry. In HIV-1 infection, IFN-gamma single positive mycobacteria-specific CD4+ T cells were decreased, while the frequency of polyfunctional cells (IFN-gamma+IL-2+TNF-alpha+) remained unchanged. Moreover, the proportion of IFN-gamma single positive cells correlated inversely with viral replication. Our results suggest that HIV-1 affects mycobacteria-specific cells differentially, depending on their functional capacity. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：25 / 30
页数：6
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