Soluble MICA in malignant diseases

被引：197
作者：
Holdenrieder, S
Stieber, P
Peterfi, A
Nagel, D
Steinle, A
Salih, HR
机构：
[1] Univ Munich, Inst Clin Chem, Univ Hosp, D-81377 Munich, Germany
[2] Univ Tubingen, Dept Internal Med 2, D-72074 Tubingen, Germany
[3] Univ Tubingen, Inst Cell Biol, Dept Immunol, D-72074 Tubingen, Germany
来源：
INTERNATIONAL JOURNAL OF CANCER | 2006年 / 118卷 / 03期
关键词：
MICA; NKG2D; serum; cancer; diagnosis; staging;
D O I：
10.1002/ijc.21382
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The immunoreceptor NKG2D activates natural killer cells and costimulates CD8 T cells. The MHC class I-related MICA molecules are ligands of NKG2D and are expressed on malignant, but not on normal, cells. As NKG2D plays an important role in the immunosurveillance of tumors, studies suggest that release of MICA from cancer cells constitutes an immune escape mechanism that systemically impairs antitumor immunity. Here, we investigated the potential of soluble MICA (sMICA) as a marker in cancer. Analysis of sMICA in sera of 512 individuals revealed significantly (p < 0.0001) higher levels in patients with various malignancies (n = 296, median 161 pg/ml) than in healthy individuals (n = 62, median < 30 pg/ml). Patients with benign diseases (n = 154, median 84 pg/ml) exhibited intermediate sMICA levels. In cancer patients, elevated sMICA levels correlated significantly with cancer stage and metastasis (p = 0.015 and p = 0.007, respectively). While release of MICA is thought to impair tumor immunity, determination of sMICA levels may provide useful additional information in the diagnosis and staging of cancer. (c) 2005 Wiley-Liss, Inc.
引用
收藏
页码：684 / 687
页数：4
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