Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States

被引：87

作者：

Endimiani, Andrea ^{[1
]}

Carias, Lenore L. ^{[1
]}

Hujer, Andrea M. ^{[1
]}

Bethel, Christopher R. ^{[1
]}

Hujer, Kristine M. ^{[1
]}

Perez, Federico ^{[2
,3
]}

Hutton, Rebecca A. ^{[1
]}

Fox, William R. ^{[4
]}

Hall, Geraldine S. ^{[4
]}

Jacobs, Michael R. ^{[5
]}

Paterson, David L. ^{[6
]}

Rice, Louis B. ^{[1
]}

Jenkins, Stephen G. ^{[7
]}

Tenover, Fred C. ^{[8
]}

Bonomo, Robert A. ^{[1
,9
]}

机构：

[1] Vet Affairs Med Ctr, Louis Stokes Cleveland Dept, Res Serv, Infect Dis Sect, Cleveland, OH 44106 USA

[2] Univ Hosp Cleveland, Case Med Ctr, HIV Med, Cleveland, OH 44106 USA

[3] Univ Hosp Cleveland, Case Med Ctr, Div Infect Dis, Cleveland, OH 44106 USA

[4] Cleveland Clin Fdn, Cleveland, OH 44195 USA

[5] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA

[6] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15212 USA

[7] Mt Sinai Med Ctr, New York, NY 10029 USA

[8] Ctr Dis Control & Prevent, Off Antimicrobial Resistance, Atlanta, GA 30333 USA

[9] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 07期

关键词：

D O I：

10.1128/AAC.00158-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The presence of plasmid-mediated quinolone resistance genes [i.e., qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA] was evaluated among 42 bla(KPC)-containing Klebsiella pneumoniae isolates collected in the eastern United States. One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids.

引用

页码：2680 / 2682

页数：3

共 17 条

[1] Emergence of the quinolone resistance-mediating gene aac(6')-Ib-cr in extended-spectrum-β-lactamase-producing Klebsiella isolates collected in Slovenia between 2000 and 2005 [J].

Avgustin, Jerneja Ambrozic ;

Keber, Rok ;

Serjavic, Katja ;

Orazem, Toni ;

Grabnar, Miklavz .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (11) :4171-4173

[2] Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City -: A new threat to our antibiotic armamentarium [J].

Bratu, S ;

Landman, D ;

Haag, R ;

Recco, R ;

Eramo, A ;

Alam, M ;

Quale, J .

ARCHIVES OF INTERNAL MEDICINE, 2005, 165 (12) :1430-1435

[3] Identification of carbapenem-resistant Klebsiella pneumoniae harboring KPC enzymes in New Jersey [J].

Chiang, Tom ;

Mariano, Noriel ;

Urban, Carl ;

Colon-Urban, Rita ;

Grenner, Louise ;

Eng, Robert H. K. ;

Huang, David ;

Dholakia, Hema ;

Rahal, James J. .

MICROBIAL DRUG RESISTANCE, 2007, 13 (04) :235-239

[4]

Clinical and laboratory Standards Institute, 2007, M100S17 CLSI

[5] Prevalence and molecular epidemiology of CTX-M extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Russian hospitals [J].

Edelstein, M ;

Pimkin, M ;

Palagin, I ;

Edelstein, I ;

Stratchounski, L .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (12) :3724-3732

[6] Carbapenem-resistant isolates of Klebsiella pneumoniae in China and detection of a conjugative plasmid (blaKPC plus qnrB4) and a blaIMP-4 gene [J].

Mendes, Rodrigo E. ;

Bell, Jan M. ;

Turnidge, John D. ;

Yang, Qiwen ;

Yu, Yunsong ;

Sun, Ziyong ;

Jones, Ronald N. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (02) :798-799

[7] Prevalence in the United States of aac(6′)-Ib-cr encoding a ciprofloxacin-modifying enzyme [J].

Park, Chi Hye ;

Robicsek, Ari ;

Jacoby, George A. ;

Sahm, Daniel ;

Hooper, David C. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (11) :3953-3955

[8] Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens:: a multicentre study from Korea [J].

Park, Yeon-Joon ;

Yu, Jin Kyung ;

Lee, Seungok ;

Oh, Eun-Jee ;

Woo, Gun-Jo .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 60 (04) :868-871

[9]

Paterson DL, 2001, CLIN MICROBIOL INFEC, V7, P709, DOI 10.1046/j.1469-0691.2001.00348.x

[10] Is plasmid-mediated quinolone resistance a clinically significant problem? [J].

Poirel, L. ;

Cattoir, V. ;

Nordmann, P. .

CLINICAL MICROBIOLOGY AND INFECTION, 2008, 14 (04) :295-297

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