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Flavones from a natural tea (the leaves of Armeniaca sibirica L.) prevent oxidative stress-induced neuronal death
被引:3
作者:

Zhang, Yan
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h-index: 0
机构:
Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

Wu, Ya-Nan
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h-index: 0
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Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

Wang, Wei
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h-index: 0
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Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

Yao, Guo-Dong
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h-index: 0
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Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

Jiang, Xue-Feng
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h-index: 0
机构:
BAIFENG Pharmaceut Co Ltd, Shenyang, Liaoning, Peoples R China
Shenyang Pharmaceut Univ, Collaborating Lab Therapeut Mat Basis & Applicat, Shenyang, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China

Song, Shao-Jiang
论文数: 0 引用数: 0
h-index: 0
机构:
Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China
机构:
[1] Shenyang Pharmaceut Univ, Minist Educ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China
[2] BAIFENG Pharmaceut Co Ltd, Shenyang, Liaoning, Peoples R China
[3] Shenyang Pharmaceut Univ, Collaborating Lab Therapeut Mat Basis & Applicat, Shenyang, Liaoning, Peoples R China
关键词:
apoptosis;
Armeniaca sibirica;
flavones;
neuroprotective activity;
oxidative stress;
ALZHEIMERS-DISEASE;
ANTIOXIDANT;
IDENTIFICATION;
DAMAGE;
DIMER;
D O I:
10.1111/jfbc.12657
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The leaves of Armeniaca sibirica L. (A. sibirica) are becoming increasingly popular as a functional natural tea, which had numerous medicinal and nutritional properties. Chemical investigation of the leaves of A. sibirica led to the isolation of nine flavones (1-9), and their structures were elucidated using NMR spectroscopic data as well as HR-ESI-MS analysis. In this study, we evaluated the potential of the isolated components to prevent H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells and 7 (quercetin-3-O-(6-O-alpha-L-rhamnopyranosyl)-beta-D-galactopyranoside) showed the greatest effect, then further investigation about the mechanism of 7 on neuro-protection was carried out. The results offered a scientific basis for the further development of A. sibirica and provided an antioxidative agent for treating oxidative stress-related disorders.
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