Characterization of secretory leukocyte protease inhibitor as an inhibitor of implantation serine proteinases

被引：3

作者：

Sharma, Navneet ^{[1
]}

Kaur, Jaspreet ^{[2
]}

Xu, Hui ^{[1
]}

zur Nieden, Nicole ^{[1
]}

Rancourt, Derrick ^{[1
]}

机构：

[1] Univ Calgary, Fac Med, Dept Biochem & Mol Biol, Calgary, AB, Canada

[2] Univ Calgary, Fac Med, Dept Clin Neurosci, Calgary, AB, Canada

来源：

MOLECULAR REPRODUCTION AND DEVELOPMENT | 2008年 / 75卷 / 07期

关键词：

serpin; serine proteinase; implantation; fertility; endometrium;

D O I：

10.1002/mrd.20855

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have recently identified and characterized two implantation serine proteinase genes, ISP1 and ISP2, which give rise to a dimeric proteinase, ISP that facilitates embryo invasion during peri-implantation period. As many proteinases have cognate serpins that regulate their proteolytic activity, we have been investigating anti-tryptases, expressed during this window of implantation. Here, we report the differential expression of secretory leukocyte protease inhibitor (SLPI) in uterine endometrium around the implantation period. The co-localization of SLPI and ISP suggests the possibility that SLPI is an ISP serpin and that expression of SLPI may lead to a reduction in ISP activity. The expression of SLPI is down regulated during the window of embryo-uterine receptivity. Our results are consistent with a model suggesting that the drop in SLPI expression may help to refine the opening of the window of implantation, by allowing the proteolytic activity of embryo invasive serine proteinases such as the ISPs.

引用

页码：1136 / 1142

页数：7