Molecular Iodine-Catalyzed N-Benzylic Sulfonamides C-N Bond Cleavage for the Decarboxylative Substitution of β-Keto Acids

被引：0
|
作者：
Jia, Lina [1 ,2 ]
Zhao, Jinyu [1 ]
Hu, Xiangping [3 ]
机构：
[1] Qiqihar Univ, Coll Chem & Chem Engn, Qiqihar 161006, Peoples R China
[2] Qiqihar Univ, Heilongjiang Prov Key Lab Catalyt Synth Fine Chem, Qiqihar 161006, Peoples R China
[3] Chinese Acad Sci, Dalian Inst Chem Phys, Lab Fine Chem, Dalian 116023, Peoples R China
来源：
LETTERS IN ORGANIC CHEMISTRY | 2022年 / 19卷 / 11期
关键词：
Decarboxylative substitution; iodine; N-benzylic sulfonamide; C-N bond cleavage; beta-keto acids; sp(3); PRIMARY ALLYLIC AMINES; MANNICH REACTION; 1,3-DICARBONYL COMPOUNDS; CARBON-NITROGEN; HALF THIOESTERS; WATER ACCESS; ALKYLATION; KETOACIDS; ALLYLATION; BENZYLATION;
D O I：
10.2174/1570178619666220516124320
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A molecular iodine-catalyzed system for the decarboxylative substitution reactions of beta-keto acids with N-benzylic sulfonamides via sp(3) C-N bond cleavage has been disclosed. This procedure provides a series of alpha-functionalized ketones in good to excellent yields. Furthermore, the practicability of this method could be manifested efficiently in a gram-scale synthesis.
引用
收藏
页码：924 / 930
页数：7
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