AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

被引：30
|
作者：
Liu, Shengnan [1 ]
Han, Jiahong [1 ]
Chang, Yulei [2 ]
Wang, Weijin [1 ]
Wang, Runlin [1 ]
Wang, Ziwei [1 ]
Li, Guangzhe [3 ]
Zhu, Dongxia [1 ]
Bryce, Martin R. [4 ]
机构：
[1] Northeast Normal Univ, Dept Chem, Key Lab Nanobiosensing & Nanobioanal Univ Jilin P, 5268 Renmin St, Changchun 130024, Jilin, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, State Key Lab Luminescence & Applicat, Changchun 130033, Jilin, Peoples R China
[3] Changchun Univ Chinese Med, Jilin Prov Sci & Technol Innovat Ctr Hlth Food Ch, Changchun 130117, Jilin, Peoples R China
[4] Univ Durham, Dept Chem, Durham DH1 3LE, England
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 72期
基金：
英国工程与自然科学研究理事会;
关键词：
AGGREGATION-INDUCED EMISSION;
D O I：
10.1039/d2cc03622c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high O-1(2) generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro. This work has potential for future photodynamic therapy (PDT) applications.
引用
收藏
页码：10056 / 10059
页数：4
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