AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

被引：30

作者：

Liu, Shengnan ^{[1
]}

Han, Jiahong ^{[1
]}

Chang, Yulei ^{[2
]}

Wang, Weijin ^{[1
]}

Wang, Runlin ^{[1
]}

Wang, Ziwei ^{[1
]}

Li, Guangzhe ^{[3
]}

Zhu, Dongxia ^{[1
]}

Bryce, Martin R. ^{[4
]}

机构：

[1] Northeast Normal Univ, Dept Chem, Key Lab Nanobiosensing & Nanobioanal Univ Jilin P, 5268 Renmin St, Changchun 130024, Jilin, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, State Key Lab Luminescence & Applicat, Changchun 130033, Jilin, Peoples R China

[3] Changchun Univ Chinese Med, Jilin Prov Sci & Technol Innovat Ctr Hlth Food Ch, Changchun 130117, Jilin, Peoples R China

[4] Univ Durham, Dept Chem, Durham DH1 3LE, England

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 72期

基金：

英国工程与自然科学研究理事会;

关键词：

AGGREGATION-INDUCED EMISSION;

D O I：

10.1039/d2cc03622c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high O-1(2) generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro. This work has potential for future photodynamic therapy (PDT) applications.

引用

页码：10056 / 10059

页数：4

共 34 条

[1] An Iridium Complex as an AIE-active Photosensitizer for Image-guided Photodynamic Therapy
Yang, Ke
Zhou, Yi
Wang, Yaping
Zhao, Shaojing
Wu, Xiaoli
Peng, Xiao
Huang, Li
Jiang, Lirong
Lan, Minhuan
Yi, Xiao-Yi
CHEMISTRY-AN ASIAN JOURNAL, 2021, 16 (13) : 1780 - 1785
[2] Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(III) complexes
Liu, Jiangping
Jin, Chengzhi
Yuan, Bo
Liu, Xingguo
Chen, Yu
Ji, Liangnian
Chao, Hui
CHEMICAL COMMUNICATIONS, 2017, 53 (12) : 2052 - 2055
[3] White light-triggered zwitterionic polymer nanoparticles based on an AIE-active photosensitizer for photodynamic antimicrobial therapy
Ren, Bibo
Li, Kaijun
Liu, Zheng
Liu, Gongyan
Wang, Haibo
JOURNAL OF MATERIALS CHEMISTRY B, 2020, 8 (47) : 10754 - 10763
[4] AIE-Active Photosensitizers: Manipulation of Reactive Oxygen Species Generation and Applications in Photodynamic Therapy
Yu, Hao
Chen, Binjie
Huang, Huiming
He, Zhentao
Sun, Jiangman
Wang, Guan
Gu, Xinggui
Tang, Ben Zhong
BIOSENSORS-BASEL, 2022, 12 (05):
[5] Living supramolecular polymerization of an AIE-active Ir(III) complex with irregular emission
Chen, Yan
Zhang, Liyan
Wang, Lei
Guo, Lin
Liu, Chun
MATERIALS CHEMISTRY FRONTIERS, 2021, 5 (21) : 7808 - 7816
[6] AIE-active Ir(III) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy
Liu, Shengnan
Han, Jiahong
Wang, Weijin
Chang, Yulei
Wang, Runlin
Wang, Ziwei
Li, Guangzhe
Zhu, Dongxia
Bryce, Martin R.
DALTON TRANSACTIONS, 2022, 51 (42) : 16119 - 16125
[7] AIE-active cyclometalated iridium(iii) complexes for highly efficient picric acid detection in aqueous media
Rabha, Monosh
Lyngkhoi, Deikrisha Lyngdoh
Patra, Sumit Kumar
Khatua, Snehadrinarayan
INORGANIC CHEMISTRY FRONTIERS, 2024, 11 (05) : 1434 - 1449
[8] AIE-active cyclometalated iridium(iii) complexes for the detection of lipopolysaccharides and wash-free imaging of bacteria
Gautam, Aryan
Gupta, Ajay
Prasad, Puja
Sasmal, Pijus K.
DALTON TRANSACTIONS, 2023, 52 (23) : 7843 - 7853
[9] An AIE-active orange-emitting cationic iridium(III) complex for latent fingerprints detection via a simple powder dusting method
Yang, Kaixin
Tang, Huaijun
Jiao, Yuxiang
Gao, Long
Zhang, Meifang
Qin, Jing
Li, Wenyao
Lu, Shiyou
He, Yonghui
JOURNAL OF LUMINESCENCE, 2023, 257
[10] Trace Ir(III) complex enhanced electrochemiluminescence of AIE-active Pdots in aqueous media
Hang Gao
Nan Zhang
Yang Li
Wei Zhao
Yiwu Quan
Yixiang Cheng
Hong-Yuan Chen
Jing-Juan Xu
Science China Chemistry, 2020, 63 : 715 - 721

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