SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF QUINAZOLINE-4(1H)-ONE DERIVATIVES AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS

被引：0
|
作者：
Mohamed, Mosaad S. [1 ]
Kamel, Mohsen M. [2 ]
Kassem, Emad M. M. [2 ]
Abotaleb, Nageh [1 ]
Khedr, M. [3 ]
Ahmed, Marwa F. [1 ]
机构：
[1] Helwan Univ, Fac Pharm, Helwan, Egypt
[2] Natl Res Ctr, Dept Therapeut Chem, Cairo, Egypt
[3] Cardiff Univ, Welsh Sch Pharm, Cardiff, S Glam, Wales
来源：
ACTA POLONIAE PHARMACEUTICA | 2011年 / 68卷 / 05期
关键词：
quinazolin-4-ones; anti-inflammatory; analgesic; ulcerogenic effect; molecular docking; IN-VITRO; POTENT; INHIBITORS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Two series of 2-phenyl-4(3H) quinazolinone derivatives have been synthesized. Most of the tested quinazolinone derivatives showed considerable potent anti-inflammatory and analgesic activity of superior GIT safety profile in experimental rats in comparing to indomethacin as reference drug. Compounds VIa, VIb were the most potent anti-inflammatory in experimental rats in comparing to indomethacin as reference drug. Docking study into COX-2 has been made for derivatives of anti-inflammatory activity.
引用
收藏
页码：665 / 675
页数：11
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