SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF QUINAZOLINE-4(1H)-ONE DERIVATIVES AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS

被引：0

作者：

Mohamed, Mosaad S. ^{[1
]}

Kamel, Mohsen M. ^{[2
]}

Kassem, Emad M. M. ^{[2
]}

Abotaleb, Nageh ^{[1
]}

Khedr, M. ^{[3
]}

Ahmed, Marwa F. ^{[1
]}

机构：

[1] Helwan Univ, Fac Pharm, Helwan, Egypt

[2] Natl Res Ctr, Dept Therapeut Chem, Cairo, Egypt

[3] Cardiff Univ, Welsh Sch Pharm, Cardiff, S Glam, Wales

来源：

ACTA POLONIAE PHARMACEUTICA | 2011年 / 68卷 / 05期

关键词：

quinazolin-4-ones; anti-inflammatory; analgesic; ulcerogenic effect; molecular docking; IN-VITRO; POTENT; INHIBITORS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two series of 2-phenyl-4(3H) quinazolinone derivatives have been synthesized. Most of the tested quinazolinone derivatives showed considerable potent anti-inflammatory and analgesic activity of superior GIT safety profile in experimental rats in comparing to indomethacin as reference drug. Compounds VIa, VIb were the most potent anti-inflammatory in experimental rats in comparing to indomethacin as reference drug. Docking study into COX-2 has been made for derivatives of anti-inflammatory activity.

引用

页码：665 / 675

页数：11

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