SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF QUINAZOLINE-4(1H)-ONE DERIVATIVES AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS

被引：0

作者：

Mohamed, Mosaad S. ^{[1
]}

Kamel, Mohsen M. ^{[2
]}

Kassem, Emad M. M. ^{[2
]}

Abotaleb, Nageh ^{[1
]}

Khedr, M. ^{[3
]}

Ahmed, Marwa F. ^{[1
]}

机构：

[1] Helwan Univ, Fac Pharm, Helwan, Egypt

[2] Natl Res Ctr, Dept Therapeut Chem, Cairo, Egypt

[3] Cardiff Univ, Welsh Sch Pharm, Cardiff, S Glam, Wales

来源：

ACTA POLONIAE PHARMACEUTICA | 2011年 / 68卷 / 05期

关键词：

quinazolin-4-ones; anti-inflammatory; analgesic; ulcerogenic effect; molecular docking; IN-VITRO; POTENT; INHIBITORS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two series of 2-phenyl-4(3H) quinazolinone derivatives have been synthesized. Most of the tested quinazolinone derivatives showed considerable potent anti-inflammatory and analgesic activity of superior GIT safety profile in experimental rats in comparing to indomethacin as reference drug. Compounds VIa, VIb were the most potent anti-inflammatory in experimental rats in comparing to indomethacin as reference drug. Docking study into COX-2 has been made for derivatives of anti-inflammatory activity.

引用

页码：665 / 675

页数：11

共 50 条

[1] Synthesis, biological evaluation and molecular docking of novel series of spiro [(2H,3H) quinazoline-2,1′- cyclohexan]-4(1H)- one derivatives as anti-inflammatory and analgesic agents
Amin, K. M.
Kamel, M. M.
Anwar, M. M.
Khedr, M.
Syam, Y. M.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (06) : 2117 - 2131
[2] Design, synthesis, anti-inflammatory evaluation, and molecular docking studies of novel quinazoline-4(3H)-one-2-carbothioamide derivatives
Nguyen, Le Thanh Hang
Vu, Dinh Hoang
Pham, Minh Quan
Ngo, Quoc Anh
Vo, Ngoc Binh
RSC ADVANCES, 2025, 15 (04) : 2850 - 2861
[3] SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF AROMATIC SULFONAMIDE DERIVATIVES AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS
Abbas, Hebat-Allah S.
El-Karim, Somaia S. Abd
Ahmed, Entesar M.
Eweas, Ahmad F.
El-Awdan, Sally A.
ACTA POLONIAE PHARMACEUTICA, 2016, 73 (05): : 1163 - 1180
[4] Synthesis, biological evaluation, and molecular docking of dihydroflavonol derivatives as anti-inflammatory agents
Yuanhang Xiang
Chunling Hu
Yuejie Zhang
Xiaochuan Ye
Medicinal Chemistry Research, 2019, 28 : 863 - 872
[5] Synthesis, biological evaluation, and molecular docking of dihydroflavonol derivatives as anti-inflammatory agents
Xiang, Yuanhang
Hu, Chunling
Zhang, Yuejie
Ye, Xiaochuan
MEDICINAL CHEMISTRY RESEARCH, 2019, 28 (06) : 863 - 872
[6] Synthesis, characterization, and investigation of the anti-inflammatory effect of 2,3-disubstituted quinazoline-4(1H)-one
Ghodge, Bhimrao
Kshirsagar, Ajay
Navghare, Vijay
BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES, 2020, 9 (01)
[7] Synthesis, characterization, and investigation of the anti-inflammatory effect of 2,3-disubstituted quinazoline-4(1H)-one
Bhimrao Ghodge
Ajay Kshirsagar
Vijay Navghare
Beni-Suef University Journal of Basic and Applied Sciences, 9
[8] Design, synthesis, biological evaluation, and molecular docking of chalcone derivatives as anti-inflammatory agents
Li, Jingfen
Li, Dong
Xu, Yiming
Guo, Zhenbo
Liu, Xu
Yang, Hua
Wu, Lichuan
Wang, Lisheng
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (03) : 602 - 606
[9] Synthesis, biological evaluation and molecular docking of spirofurochromanone derivatives as anti-inflammatory and antioxidant agents
Ashok, D.
Madhuri, E. V. L.
Sarasija, M.
Kanth, S. Sree
Vijjulatha, M.
Alaparthi, Malini D.
Sagurthi, R.
RSC ADVANCES, 2017, 7 (41) : 25710 - 25724
[10] Design, synthesis, and biological evaluation of novel imidazole derivatives as analgesic and anti-inflammatory agents: experimental and molecular docking insights
Muheyuddeen, Gulam
Khan, Mohd Yaqub
Ahmad, Tanzeem
Srivastava, Shriyansh
Verma, Stuti
Ansari, Mo. Suheb
Sahu, Nilanchala
SCIENTIFIC REPORTS, 2024, 14 (01):

← 1 2 3 4 5 →