Amyloid fibrils: modulation of formation and structure by copper(II)

被引：24
|
作者：
Pradines, Vincent [1 ]
Stroia, Alina Jurca [1 ]
Faller, Peter [1 ]
机构：
[1] Univ Toulouse 3, CNRS, Chim Coordinat Lab, F-31077 Toulouse, France
来源：
NEW JOURNAL OF CHEMISTRY | 2008年 / 32卷 / 07期
关键词：
D O I：
10.1039/b719556g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The role of Cu(II)-complexation of amyloidogenic peptides on the formation and structure of aggregates were analyzed in order to obtain a general insight into modulation of peptide aggregation by metal ions. The results mimicked various facets of biological relevant peptides/protein-aggregation. Important mechanistic features are the ability of Cu(II) to associate the peptides by bridging coordination, the structural changes induced by Cu(II) binding and their effect on peptide-peptide interactions.
引用
收藏
页码：1189 / 1194
页数：6
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