Profound Vasoplegia During Sacubitril/Valsartan Treatment After Heart Transplantation

被引：18

作者：

Almufleh, Aws ^{[1
,2
]}

Mielniczuk, Lisa M. ^{[1
]}

Zinoviev, Radoslav ^{[3
]}

Moeller, Andrew ^{[1
]}

Davies, Ross A. ^{[1
]}

Stadnick, Ellamae ^{[1
]}

Chan, Vincent ^{[4
]}

Chih, Sharon ^{[1
]}

机构：

[1] Univ Ottawa, Inst Heart, Div Cardiol, 40 Ruskin St,H-1295, Ottawa, ON K1Y 4W7, Canada

[2] King Saud Univ, Cardiac Sci Dept, Riyadh, Saudi Arabia

[3] Johns Hopkins Univ Hosp, Dept Med, Baltimore, MD 21287 USA

[4] Univ Ottawa, Inst Heart, Dept Surg, Ottawa, ON, Canada

来源：

CANADIAN JOURNAL OF CARDIOLOGY | 2018年 / 34卷 / 03期

关键词：

NEPRILYSIN; FAILURE; LCZ696;

D O I：

10.1016/j.cjca.2017.12.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vasoplegia occurs in up to 16% of patients who undergo heart transplantation (HT) and is associated with significant morbidity and mortality. We present a case of a 61-year-old man with ischemic cardiomyopathy receiving sacubitril/valsartan (Entresto; Novartis, Cambridge, MA) who developed profound hypotension after HT. He was treated with intravenous methylene blue and high-dose vasopressors, but developed acute kidney injury requiring dialysis and a prolonged stay in the intensive care unit. This case supports a potent vasodilatory effect of sacubitril/valsartan, and if confirmed by other studies, might warrant consideration for withholding treatment while awaiting HT, particularly in patients with risk factors for vasoplegia.

引用

页码：343.e5 / 343.e7

页数：3

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