Dedicated Photoacoustic Imaging Instrument for Human Periphery Blood Vessels: A New Paradigm for Understanding the Vascular Health

被引：22

作者：

Chen, Tao ^{[1
]}

Liu, Liangjian ^{[1
,2
,3
]}

Ma, Xiaohui ^{[4
]}

Zhang, Ying ^{[5
]}

Liu, Huadong ^{[6
]}

Zheng, Rongqin ^{[7
]}

Ren, Jie ^{[7
]}

Zhou, Huichao ^{[7
]}

Ren, Yaguang ^{[1
]}

Gao, Rongkang ^{[1
]}

Chen, Ningbo ^{[1
]}

Zheng, Hairong ^{[8
]}

Song, Liang ^{[1
]}

Liu, Chengbo ^{[1
]}

机构：

[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Biomed Opt & Mol Imaging, Shenzhen 518055, Guangdong, Peoples R China

[2] Univ Chinese Acad Sci China, Shenzhen Coll Adv Technol, Shenzhen, Peoples R China

[3] Natl Innovat Ctr Adv Med Devices, Shenzhen, Peoples R China

[4] Chinese Peoples Liberat Army Gen Hosp, Dept Vasc Surg, Beijing, Peoples R China

[5] Xian Univ Architecture & Technol, Sch Mech & Elect Engn, Xian, Peoples R China

[6] Shenzhen Peoples Hosp, Dept Cardiol, Shenzhen, Peoples R China

[7] Sun Yat Sen Univ, Affiliated Hosp 3, Guangdong Key Lab Liver Dis Res, Dept Ultrasound, Guangzhou, Peoples R China

[8] Chinese Acad Sci, Shenzhen Inst Adv Technol, Lauterbur Res Ctr Biomed Imaging, Shenzhen 518055, Guangdong, Peoples R China

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2022年 / 69卷 / 03期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Imaging; Skin; Spatial resolution; Ultrasonic imaging; Three-dimensional displays; Data visualization; Visualization; Photoacoustic tomography; vascular imaging; peripheral vascular disease; ARTERIAL OCCLUSIVE DISEASE; OPTICAL-PROPERTIES; TOMOGRAPHY; MORTALITY; SKIN;

D O I：

10.1109/TBME.2021.3113764

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel photoacoustic imaging system based on a semi-ring transducer array is proposed to image peripheral blood vessels. The system's penetration depth is deep (similar to 15 mm) with high spatial (similar to 200 mu m) and temporal resolution. In a clinical study, volumetric photoacoustic data of limbs were obtained within the 50s (for a FOV of 15 cm x 4 cm) with the volunteers in the standing and sitting posture. Compared to the previous studies, our system has many advantages, including (1) Larger field of view; (2) Finer elevational and in-plane resolutions; (3) Enhanced 3D visualization of peripheral vascular networks; (4) Compact size and better portability. The 3D visualization and cross-sectional images of five healthy volunteers clearly show the vascular network and the system's ability to image submillimeter blood vessels. This high-resolution PA system has great potential for imaging human periphery vasculatures noninvasively in clinical research.

引用

页码：1093 / 1100

页数：8

共 3 条

[1] Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array
Toi, M.
Asao, Y.
Matsumoto, Y.
Sekiguchi, H.
Yoshikawa, A.
Takada, M.
Kataoka, M.
Endo, T.
Kawaguchi-Sakita, N.
Kawashima, M.
Fakhrejahani, E.
Kanao, S.
Yamaga, I.
Nakayama, Y.
Tokiwa, M.
Torii, M.
Yagi, T.
Sakurai, T.
Togashi, K.
Shiina, T.
SCIENTIFIC REPORTS, 2017, 7
[2] Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array
M. Toi
Y. Asao
Y. Matsumoto
H. Sekiguchi
A. Yoshikawa
M. Takada
M. Kataoka
T. Endo
N. Kawaguchi-Sakita
M. Kawashima
E. Fakhrejahani
S. Kanao
I. Yamaga
Y. Nakayama
M. Tokiwa
M. Torii
T. Yagi
T. Sakurai
K. Togashi
T. Shiina
Scientific Reports, 7
[3] Imaging of human peripheral blood vessels during cuff occlusion with a compact LED-based photoacoustic and ultrasound system
Xia, Wenfeng
Maneas, Efthymios
Nam Trung Huynh
Singh, Mithun Kuniyil Ajith
Brown, Nina Montana
Ourselin, Sebastien
Gilbert-Kawai, Edward
West, Simeon J.
Desjardins, Adrien E.
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2019, 2019, 10878

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