Polyphenols as antimicrobial agents

被引：1088

作者：

Daglia, Maria ^{[1
]}

机构：

[1] Univ Pavia, Dept Drug Sci, I-27100 Pavia, Italy

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2012年 / 23卷 / 02期

关键词：

RESISTANT STAPHYLOCOCCUS-AUREUS; GREEN TEA POLYPHENOLS; EPIGALLOCATECHIN GALLATE; ESCHERICHIA-COLI; ANTIBIOTIC-ACTIVITY; PHENOLIC-COMPOUNDS; NATURAL-PRODUCTS; BERRY PHENOLICS; IN-VITRO; METHICILLIN;

D O I：

10.1016/j.copbio.2011.08.007

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyphenols are secondary metabolites produced by higher plants, which play multiple essential roles in plant physiology and have potential healthy properties on human organism, mainly as antioxidants, anti-allergic, anti-inflammatory, anticancer, antihypertensive, and antimicrobial agents. In the present review the antibacterial, antiviral, and antifungal activities of the most active polyphenol classes are reported, highlighting, where investigated, the mechanisms of action and the structure-activity relationship. Moreover, considering that the microbial resistance has become an increasing global problem, and there is a compulsory need to find out new potent antimicrobial agents as accessories to antibiotic therapy, the synergistic effect of polyphenols in combination with conventional antimicrobial agents against clinical multidrug-resistant microorganisms is discussed.

引用

收藏

页码：174 / 181

页数：8

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