A simple and efficient approach to the synthesis of 4H-furo[3,4-b]pyrans via a three-component reaction of isocyanides

被引：53

作者：

Shaabani, Ahmad ^{[1
]}

Soleimani, Ebrahim ^{[1
]}

Sarvary, Afshin ^{[1
]}

Rezayan, Ali Hossein ^{[1
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Dept Chem, Tehran 198394716, Iran

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 14期

关键词：

multi-component reaction; isocyanide; tetronic acid; 4H-furo[3,4-b]pyran;

D O I：

10.1016/j.bmcl.2008.06.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and tetronic acid in dichloromethane at room temperature afforded 4H-furo[3,4-b]pyran derivatives. These compounds are closely related with ring systems, TAN-2483B, TAN-2483A, and FD-211 which have a broad spectrum of biological activity. (c) 2008 Published by Elsevier Ltd.

引用

页码：3968 / 3970

页数：3

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