A simple and efficient approach to the synthesis of 4H-furo[3,4-b]pyrans via a three-component reaction of isocyanides

被引：53
|
作者：
Shaabani, Ahmad [1 ]
Soleimani, Ebrahim [1 ]
Sarvary, Afshin [1 ]
Rezayan, Ali Hossein [1 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Dept Chem, Tehran 198394716, Iran
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 14期
关键词：
multi-component reaction; isocyanide; tetronic acid; 4H-furo[3,4-b]pyran;
D O I：
10.1016/j.bmcl.2008.06.014
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and tetronic acid in dichloromethane at room temperature afforded 4H-furo[3,4-b]pyran derivatives. These compounds are closely related with ring systems, TAN-2483B, TAN-2483A, and FD-211 which have a broad spectrum of biological activity. (c) 2008 Published by Elsevier Ltd.
引用
收藏
页码：3968 / 3970
页数：3
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