A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL

被引：47

作者：

Best, O. G. ^{[1
]}

Gardiner, A. C. ^{[1
]}

Majid, A. ^{[2
]}

Walewska, R. ^{[2
]}

Austen, B. ^{[3
]}

Skowronska, A. ^{[3
]}

Ibbotson, R. ^{[1
]}

Stankovic, T. ^{[3
]}

Dyer, M. J. S. ^{[2
]}

Oscier, D. G. ^{[1
]}

机构：

[1] Royal Bournemouth Hosp, Bournemouth, Dorset, England

[2] MRC, Toxicol Unit, Leicester, Leics, England

[3] Univ Birmingham, Div Canc Studies, Birmingham, W Midlands, England

来源：

LEUKEMIA | 2008年 / 22卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/sj.leu.2405092

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1456 / 1459

页数：4

共 8 条

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[2] Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion
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[5] Imperfect correlation between p53 dysfunction and deletion of TP53 and ATM in chronic lymphocytic leukaemia
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[6] Detection of p53 dysfunction by flow cytometry in chronic lymphocytic leukaemia
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[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2004, 127 (04) : 425 - 428
[7] JONES GG, 2005, LEUK LYMPHOMA S1, V46, pS56
[8] Oscier DG, 2006, BLOOD, V108, p92A

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