Cell-free DNA as a novel marker in cancer therapy

被引：0

作者：

Kato, Shumei ^{[1
]}

Janku, Filip ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA

来源：

BIOMARKERS IN MEDICINE | 2015年 / 9卷 / 07期

基金：

美国国家卫生研究院;

关键词：

cancer; cell-free DNA; liquid biopsy; personalized medicine; CIRCULATING TUMOR DNA; TYROSINE KINASE INHIBITORS; METASTATIC BREAST-CANCER; ERDHEIM-CHESTER DISEASE; BRAF MUTATIONS; ACQUIRED-RESISTANCE; INTRATUMOR HETEROGENEITY; COLORECTAL-CANCER; PLASMA; KRAS;

D O I：

10.2217/BMM.15.38

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Advances in next-generation sequencing have provided new insights and new therapeutic options for patients with cancer. However, assessment of genomic aberrations, which is required for precision medicine, has been challenging because of the difficulties in capturing intratumoral heterogeneity and in real-time assessment of tumors. Recent advances in technology have enabled detection and analysis of cell-free DNA in cancer patients, which provides real-time assessment of tumor evolution. Here, we review the recent advances in our understanding of the clinical utility of cell-free DNA and the future directions for its use in cancer management.

引用

页码：703 / 712

页数：10

共 50 条

[41] Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review
Vymetalkova, Veronika
Cervena, Klara
Bartu, Linda
Vodicka, Pavel
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (11)
[42] Cell-free DNA methylation in the clinical management of lung cancer
Ezegbogu, Mark
Wilkinson, Emma
Reid, Glen
Rodger, Euan J.
Brockway, Ben
Russell-Camp, Takiwai
Kumar, Rajiv
Chatterjee, Aniruddha
TRENDS IN MOLECULAR MEDICINE, 2024, 30 (05) : 499 - 515
[43] Circulating cell-free mitochondrial DNA as a novel cancer biomarker: opportunities and challenges
Yu, Man
MITOCHONDRIAL DNA, 2012, 23 (05): : 329 - 332
[44] The Potential of Cell-Free DNA in Cancer: towards Standardization and Optimization for Enhanced Diagnosis and Monitoring
Khurram, Iqra
Khan, Muhammad Umer
Saleem, Ayman
Ibrahim, Saooda
Ghani, Muhammad Usman
Shahid, Muhammad
Amin, Iram
Calina, Daniela
Sharifi-Rad, Javad
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2024, 38 (04): : 2713 - 2732
[45] Sensitive Quantification of Cell-Free Tumor DNA for Early Detection of Recurrence in Colorectal Cancer
Stasik, Sebastian
Mende, Marika
Schuster, Caroline
Mahler, Sandra
Aust, Daniela
Tannapfel, Andrea
Reinacher-Schick, Anke
Baretton, Gustavo
Krippendorf, Claudia
Bornhaeuser, Martin
Ehninger, Gerhard
Folprecht, Gunnar
Thiede, Christian
FRONTIERS IN GENETICS, 2022, 12
[46] Use of Circulating Cell-Free DNA to Guide Precision Medicine in Patients with Colorectal Cancer
Morris, Van K.
Strickler, John H.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021, 2021, 72 : 399 - 413
[47] Liquid biopsies based on cell-free DNA as a potential biomarker in head and neck cancer
Rapado-Gonzalez, Oscar
Rodriguez-Ces, Ana Maria
Lopez-Lopez, Rafael
Suarez-Cunqueiro, Maria Mercedes
JAPANESE DENTAL SCIENCE REVIEW, 2023, 59 : 289 - 302
[48] Plasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer
Fernandez-Garcia, Daniel
Hills, Allison
Page, Karen
Hastings, Robert K.
Toghill, Bradley
Goddard, Kate S.
Ion, Charlotte
Ogle, Olivia
Boydell, Anna Rita
Gleason, Kelly
Rutherford, Mark
Lim, Adrian
Guttery, David S.
Coombes, R. Charles
Shaw, Jacqueline A.
BREAST CANCER RESEARCH, 2019, 21 (01)
[49] An Investigation into Cell-Free DNA in Different Common Cancers
Nafar, Samira
Hosseini, Kamran
Shokrgozar, Negin
Farahmandi, Amir Yousef
Alamdari-Palangi, Vahab
Sichani, Ali Saber
Fallahi, Jafar
MOLECULAR BIOTECHNOLOGY, 2023, 66 (12) : 3462 - 3474
[50] Cell-Free DNA for the Management of Classical Hodgkin Lymphoma
Camus, Vincent
Jardin, Fabrice
PHARMACEUTICALS, 2021, 14 (03)

← 1 2 3 4 5 →