Cell-free DNA as a novel marker in cancer therapy

被引：0

作者：

Kato, Shumei ^{[1
]}

Janku, Filip ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA

来源：

BIOMARKERS IN MEDICINE | 2015年 / 9卷 / 07期

基金：

美国国家卫生研究院;

关键词：

cancer; cell-free DNA; liquid biopsy; personalized medicine; CIRCULATING TUMOR DNA; TYROSINE KINASE INHIBITORS; METASTATIC BREAST-CANCER; ERDHEIM-CHESTER DISEASE; BRAF MUTATIONS; ACQUIRED-RESISTANCE; INTRATUMOR HETEROGENEITY; COLORECTAL-CANCER; PLASMA; KRAS;

D O I：

10.2217/BMM.15.38

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Advances in next-generation sequencing have provided new insights and new therapeutic options for patients with cancer. However, assessment of genomic aberrations, which is required for precision medicine, has been challenging because of the difficulties in capturing intratumoral heterogeneity and in real-time assessment of tumors. Recent advances in technology have enabled detection and analysis of cell-free DNA in cancer patients, which provides real-time assessment of tumor evolution. Here, we review the recent advances in our understanding of the clinical utility of cell-free DNA and the future directions for its use in cancer management.

引用

页码：703 / 712

页数：10

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