An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese

被引：40

作者：

Zhang, Guoliang ^{[2
]}

Chen, Xinchun ^{[2
]}

Chan, Long ^{[1
,3
]}

Zhang, Mingxia ^{[2
]}

Zhu, Baohua ^{[4
]}

Wang, Lantian ^{[2
]}

Zhu, Xiuyun ^{[2
]}

Zhang, Jieyun ^{[2
]}

Zhou, Boping ^{[2
]}

Wang, Junwen ^{[1
]}

机构：

[1] Univ Hong Kong, LKS Fac Med, Dept Biochem, Pokfulam, Hong Kong, Peoples R China

[2] Guangdong Med Coll, Shenzhen Third Peoples Hosp, Shenzhen Hong Kong Inst Infect Dis, Shenzhen 518020, Peoples R China

[3] Carleton Coll, Dept Math, Northfield, MN 55057 USA

[4] GuangDong Med Coll, Affiliated Clin Coll 1, Dept Surg, Zhanjiang 524023, Peoples R China

来源：

SCIENTIFIC REPORTS | 2011年 / 1卷

基金：

美国国家科学基金会;

关键词：

GENOME-WIDE ASSOCIATION; INTERFERON-GAMMA; POTENTIAL ROLE; HOST-DEFENSE; BINDING; EXPRESSION; DATABASE; INTERLEUKIN-22; MEMORY; GENES;

D O I：

10.1038/srep00020

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45-0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.

引用

页数：6

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