Huperzine A: A Mini-Review of Biological Characteristics, Natural Sources, Synthetic Origins, and Future Prospects

被引：6
作者：
Yang, H. L. [1 ]
Ma, Y. S. [1 ]
Wang, X. L. [1 ]
Zhu, D. [1 ,2 ]
机构：
[1] Jiangxi Normal Univ, Key Lab Protect & Utilizat Subtrop Plant Resource, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China
[2] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Funct Organ Mol, Nanchang 330013, Jiangxi, Peoples R China
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 01期
基金：
中国国家自然科学基金;
关键词：
acetylcholinesterase inhibition; Alzheimer's disease; bioprocessing; Huperzine A; natural products; SERRATA; IDENTIFICATION; CYCLIZATION; FUNGUS;
D O I：
10.1134/S1070428020010236
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Huperzia serrate is a known medicinal plant that produces the Lycopodium alkaloid Huperzine A (HupA). It has been used to treat such diseases as contusions, swellings, and pain since the year of 739. Chemical structure analyses show that HupA exists as two stereoisomers, (-)-HupA and (+)-HupA. The review was aimed to summarize the recent literature data about the biological characteristics, natural sources, synthetic origins, and future prospects in order to provide enhanced understanding of the properties of Huperzine A, and to supply a fundamental framework for the future studies of H. serrata.
引用
收藏
页码：148 / 157
页数：10
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