Three-Dimensional Electro-Anatomical Mapping and Myocardial Work Performance during Spontaneous Rhythm, His Bundle Pacing and Right Ventricular Pacing: The EMPATHY Study

被引:4
作者
Malagu, Michele [1 ]
Vitali, Francesco [1 ]
Massafra, Rodolfo Francesco [1 ]
Cardelli, Laura Sofia [1 ]
Pavasini, Rita [1 ]
Guardigli, Gabriele [1 ]
Rapezzi, Claudio [1 ]
Bertini, Matteo [1 ]
机构
[1] Azienda Osped Univ Ferrara, Cardiol Unit, Via Aldo Moro 8, I-44124 Ferrara, Italy
关键词
pacemaker; physiology; electrophysiology; electromechanical; speckle tracking; strain; RECOMMENDATIONS; QUANTIFICATION; ASSOCIATION; THERAPY; SOCIETY; INDEX; AREA;
D O I
10.3390/jcdd9110377
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. His bundle pacing (HBP) has emerged as an alternative site to right ventricular pacing (RVP) with encouraging outcomes. To date, no study has investigated the systematic approach of three-dimensional electroanatomic mapping (3D-EAM) to guide HBP implantation and to evaluate myocardial activation timing. Furthermore, studies reporting a comprehensive assessment of the ventricular function, using myocardial work (MW) evaluation are lacking. Objectives. (1) To evaluate the systematic use of the 3D-EAM as a guide to HBP; (2) to assess the electrical and mechanical activations with high-density mapping, comparing spontaneous ventricular activation (SVA), HBP and RVP; (3) to assess the myocardial function through speckle-tracking echocardiography (STE) and MW analysis in SVA, HBP and RVP. Methods. 3D-EAM was performed in consecutive patients undergoing HBP implantation with a low use of fluoroscopy. All patients were systematically evaluated with high-density mapping, MW and STE. Results. Fifteen patients were enrolled, of whom three had an implant failure (20%). RV activation time was not statistically different between SVA and HBP (103 vs. 104 ms, p = 0.969) but was significantly higher in RVP (133 ms, p = 0.011 vs. SVA and p = 0.001 vs HBP). Global constructive work was significantly lower during RVP (1191 mmHg%) than during SVA and HBP (1648 and 1505 mmHg%, p = 0.011 and p = 0.008, respectively) and did not differ between SVA and HBP (p = 0.075). Conclusions. 3D-EAM and MW evaluation showed that HBP was comparable to the physiological SVA in terms of activation time and cardiac performance. Compared to both SVA and HBP, RVP was associated with a worse activation timing and ventricular efficiency.
引用
收藏
页数:11
相关论文
共 25 条
  • [1] Management of macro-reentrant right atrial tachycardia around multiple leads aided by high-density mapping
    Bertini, Matteo
    Mele, Daniela
    Vitali, Francesco
    Balla, Cristina
    Malagu, Michele
    [J]. REVIEWS IN CARDIOVASCULAR MEDICINE, 2022, 23 (01)
  • [2] Myocardial work by echocardiography: a novel method ready for clinical testing
    Boe, Espen
    Skulstad, Helge
    Smiseth, Otto A.
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2019, 20 (01) : 18 - 20
  • [3] Non-invasive myocardial work index identifies acute coronary occlusion in patients with non-ST-segment elevation-acute coronary syndrome
    Boe, Espen
    Russell, Kristoffer
    Eek, Christian
    Eriksen, Morten
    Remme, EspenW.
    Smiseth, Otto A.
    Skulstad, Helge
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2015, 16 (11) : 1247 - 1255
  • [4] Variable Arrangement of the Atrioventricular Conduction Axis Within the Triangle of Koch Implications for Permanent His Bundle Pacing
    Cabrera, Jose-Angel
    Anderson, Robert H.
    Macias, Yolanda
    Nevado-Medina, Jorge
    Porta-Sanchez, Andreu
    Rubio, Jose Manuel
    Sanchez-Quintana, Damian
    [J]. JACC-CLINICAL ELECTROPHYSIOLOGY, 2020, 6 (04) : 362 - 377
  • [5] Permanent His-bundle pacing maintains long-term ventricular synchrony and left ventricular performance, unlike conventional right ventricular apical pacing
    Catanzariti, Domenico
    Maines, Massimiliano
    Manica, Anna
    Angheben, Carlo
    Varbaro, Annamaria
    Vergara, Giuseppe
    [J]. EUROPACE, 2013, 15 (04): : 546 - 553
  • [6] Permanent direct his bundle pacing does not induce ventricular dyssynchrony unlike conventional right ventricular apical pacing - An intrapatient acute comparison study
    Catanzariti, Domenico
    Maines, Massimiliano
    Cemin, Claudio
    Broso, Gianpaolo
    Marotta, Tiziana
    Vergara, Giuseppe
    [J]. JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 2006, 16 (02) : 81 - 92
  • [7] A new approach to assess myocardial work by non-invasive left ventricular pressure-strain relations in hypertension and dilated cardiomyopathy
    Chan, Jonathan
    Edwards, Natalie F. A.
    Khandheria, Bijoy K.
    Shiino, Kenji
    Sabapathy, Surendran
    Anderson, Bonita
    Chamberlain, Robert
    Scalia, Gregory M.
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2019, 20 (01) : 31 - 39
  • [8] Direct his-bundle pacing: Present and future
    Deshmukh, PM
    Romanyshyn, M
    [J]. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2004, 27 (06): : 862 - 870
  • [9] Role of myocardial constructive work in the identification of responders to CRT
    Galli, Elena
    Leclercq, Christophe
    Hubert, Arnaud
    Bernard, Anne
    Smiseth, Otto A.
    Mabo, Philippe
    Samset, Eigil
    Hernandez, Alfredo
    Donal, Erwan
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2018, 19 (09) : 1010 - 1018
  • [10] 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA)
    Glikson, Michael
    Nielsen, Jens Cosedis
    Kronborg, Mads Brix
    Michowitz, Yoav
    Auricchio, Angelo
    Barbash, Israel Moshe
    Barrabes, Jose A.
    Boriani, Giuseppe
    Braunschweig, Frieder
    Brignole, Michele
    Burri, Haran
    Coats, Andrew J. S.
    Deharo, Jean-Claude
    Delgado, Victoria
    Diller, Gerhard-Paul
    Israel, Carsten W.
    Keren, Andre
    Knops, Reinoud E.
    Kotecha, Dipak
    Leclercq, Christophe
    Merkely, Bela
    Starck, Christoph
    Thylen, Ingela
    Maria Tolosana, Jose
    [J]. EUROPEAN HEART JOURNAL, 2021, 42 (35) : 3427 - 3520