Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? - A case report

被引：2

作者：

Berek, Klaus ^{[1
]}

Beer, Ronny ^{[1
]}

Grams, Astrid ^{[2
]}

Helbok, Raimund ^{[1
]}

Lindner, Anna ^{[1
]}

Pfausler, Bettina ^{[1
]}

Schiefecker, Alois ^{[1
]}

Deisenhammer, Florian ^{[1
]}

Hegen, Harald ^{[1
]}

机构：

[1] Med Univ Innsbruck, Dept Neurol, Anichstr 35, A-6020 Innsbruck, Austria

[2] Med Univ Innsbruck, Dept Neuroradiol, Innsbruck, Austria

来源：

BMC NEUROLOGY | 2022年 / 22卷 / 01期

关键词：

Case report; Herpes simplex virus; Caspr2; VGKC; Autoimmunity; NMDA-RECEPTOR ENCEPHALITIS; CEREBROSPINAL-FLUID;

D O I：

10.1186/s12883-022-02637-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies. Case presentation We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2). Conclusion This is the first report of a patient with encephalitis who tested positive for HSV as well as for Caspr2 antibodies.

引用

页数：6

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