In Vivo and In Vitro Models of Diabetes: A Focus on Pregnancy

被引：8
作者：
Lilao-Garzon, Joaquin [1 ]
Valverde-Tercedor, Carmen [1 ]
Munoz-Descalzo, Silvia [1 ]
Brito-Casillas, Yeray [1 ]
Wagner, Ana M. [1 ,2 ]
机构：
[1] Univ Las Palmas Gran Canaria ULPGC, Inst Univ Invest Biomed & Sanitarias IUIBS, Las Palmas Gran Canaria, Islas Canarias, Spain
[2] Complejo Hosp Univ Insular Maternoinfantil Gran C, Serv Endocrinol & Nutr, Las Palmas Gran Canaria, Spain
来源：
DIABETES: FROM RESEARCH TO CLINICAL PRACTICE, VOL 4 | 2021年 / 1307卷
关键词：
Animal model; Embryo culture; Fertility; Gestation; Gestational diabetes; In vitro model; Intrauterine programing; Organoids; Pregestational diabetes; Streptozotocin; BETA-CELL LINE; ENDOPLASMIC-RETICULUM STRESS; HUMAN CHORIONIC-GONADOTROPIN; EPITHELIAL BARRIER FUNCTION; ACTIVATED-RECEPTOR-GAMMA; COLONY-FORMING CELLS; EMBRYONIC STEM-CELLS; PANCREATIC PROGENITORS; INSULIN-RESISTANCE; TROPHOBLAST CELLS;
D O I：
10.1007/5584_2020_536
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes in pregnancy is associated with an increased risk of poor outcomes, both for the mother and her offspring. Although clinical and epidemiological studies are invaluable to assess these outcomes and the effectiveness of potential treatments, there are certain ethical and practical limitations to what can be assessed in human studies. Thus, both in vivo and in vitro models can aid us in the understanding of the mechanisms behind these complications and, in the long run, towards their prevention and treatment. This review summarizes the existing animal and cell models used to mimic diabetes, with a specific focus on the intrauterine environment.
引用
收藏
页码：553 / 576
页数：24
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