Alzheimer Disease and Its Growing Epidemic Risk Factors, Biomarkers, and the Urgent Need for Therapeutics

被引：111

作者：

Hickman, Richard A. ^{[1
]}

Faustin, Arline ^{[2
,3
]}

Wisniewski, Thomas ^{[2
,3
,4
]}

机构：

[1] NYU, Dept Pathol, Sch Med, Alexandria ERSP, 450 East 29th St, New York, NY 10016 USA

[2] NYU, Dept Pathol, Sch Med, Ctr Cognit Neurol,Alexandria ERSP, 450 East 29th St, New York, NY 10016 USA

[3] NYU, Dept Neurol, Sch Med, Ctr Cognit Neurol,Alexandria ERSP, 450 East 29th St, New York, NY 10016 USA

[4] NYU, Dept Psychiat, Sch Med, Ctr Cognit Neurol,Alexandria ERSP, 450 East 29th St, New York, NY 10016 USA

来源：

NEUROLOGIC CLINICS | 2016年 / 34卷 / 04期

关键词：

Alzheimer disease; Risk factors; Biomarkers; Epidemiology; TRAUMATIC BRAIN-INJURY; MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA PLAQUES; APOLIPOPROTEIN-E; HEAD-INJURY; A-BETA; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; NATIONAL INSTITUTE; GLOBAL PREVALENCE;

D O I：

10.1016/j.ncl.2016.06.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer disease (AD) represents one of the greatest medical challenges of this century; the condition is becoming increasingly prevalent worldwide and no effective treatments have been developed for this terminal disease. Because the disease manifests at a late stage after a long period of clinically silent neurodegeneration, knowledge of the modifiable risk factors and the implementation of biomarkers is crucial in the primary prevention of the disease and presymptomatic detection of AD, respectively. This article discusses the growing epidemic of AD and antecedent risk factors in the disease process. Disease biomarkers are discussed, and the implications that this may have for the treatment of this currently incurable disease.

引用

页码：941 / +

页数：14

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