Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice

被引：12
|
作者：
Khoretonenko, MV
Vorovitch, MF
Zakharova, LG
Pashvykina, GV
Ovsyannikova, NV
Stephenson, JR
Timofeev, AV
Altstein, AD
Shneider, AM
机构：
[1] RAS, Inst Gene Biol, Moscow 119334, Russia
[2] RAMS, Chumakov Inst Poliomyelitis & Viral Encephalitide, Moscow, Russia
[3] London Sch Hyg & Trop Med, London WC1, England
[4] Cure Lab Inc, Stoughton, MA USA
来源：
IMMUNOLOGY LETTERS | 2003年 / 90卷 / 2-3期
关键词：
tick-borne encephalitis virus; vaccinia virus; NS1; protein; protective activity;
D O I：
10.1016/j.imlet.2003.09.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A vaccinia virus recombinant containing the non-structural tick-borne encephalitis virus (TBEV) NS1 gene was developed. The recombinant expressed native dimeric form of the NS1 protein in infected cells and protected mice against lethal infection with TBEV. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：161 / 163
页数：3
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