Single molecule nanobioscience

被引：166

作者：

Ishijima, A ^{[1
]}

Yanagida, T

机构：

[1] Nagoya Univ, Sch Engn, Dept Appl Phys, Chikusa Ku, Nagoya, Aichi 46401, Japan

[2] JST, ICORP, Single Mol Proc Project, Osaka, Japan

[3] Osaka Univ, Grad Sch Engn Sci, Dept Syst & Human Sci, Osaka, Japan

[4] Osaka Univ, Grad Sch Med, Dept Physiol & Biosignaling, Osaka, Japan

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(01)01860-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the rapid development and progress of single-molecule detection techniques have opened up a new era of biological research. The advantage of single-molecule studies is that data are not obscured by the ensemble-averaged measurements inherent in classical biochemical experiments. These techniques are shedding light on the dynamic and mechanistic properties of molecular machines, both in vivo and in vitro. This review summarizes the single-molecule experiments that have been designed to investigate molecular motors, enzyme reactions, protein dynamics, DNA transcription and cell signaling.

引用

页码：438 / 444

页数：7

共 41 条

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