Comparison of effects of pitavastatin and atorvastatin on plasma coenzyme Q10 in heterozygous familial hypercholesterolemia: Results from a crossover study

被引:31
|
作者
Kawashiri, M-a [1 ]
Nohara, A. [2 ]
Tada, H. [1 ]
Mori, M. [1 ]
Tsuchida, M. [1 ]
Katsuda, S. [1 ]
Inazu, A. [3 ]
Kobayashi, J. [2 ]
Koizumi, J. [4 ]
Mabuchi, H. [2 ]
Yamagishi, M. [1 ]
机构
[1] Kanazawa Univ, Grad Sch Med Sci, Dept Internal Med, Div Cardiovasc Med, Kanazawa, Ishikawa, Japan
[2] Kanazawa Univ, Grad Sch Med Sci, Dept Lipidol, Kanazawa, Ishikawa, Japan
[3] Kanazawa Univ, Grad Sch Med Sci, Dept Lab Sci, Mol Biochem & Mol Biol Lab, Kanazawa, Ishikawa, Japan
[4] Kanazawa Univ, Kanazawa Univ Hosp, Dept Gen Med, Kanazawa, Ishikawa, Japan
关键词
D O I
10.1038/sj.clpt.6100396
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
An open, randomized, four-phased crossover study using 4mg of pitavastatin or 20mg of atorvastatin was performed to compare their efficacy and safety, especially regarding plasma levels of coenzyme Q10 (CoQ10) in 19 Japanese patients with heterozygous familial hypercholesterolemia. Pitavastatin and atorvastatin caused significant and almost comparable reductions in serum levels of total cholesterol (-35.4 vs. -33.8%), low-density lipoprotein cholesterol (-42.8 vs. -40.7%), and triglyceride (-26.1 vs. -29.4%), and significantly increased serum levels of high-density lipoprotein cholesterol (12.1 vs. 11.4%). Under these conditions, plasma levels of CoQ10 were reduced by atorvastatin (-26.1%, P = 0.0007) but not by pitavastatin (-7.7%, P = 0.39), although no adverse events or abnormalities of liver and muscle enzyme were observed after either statin treatment. It remains to be seen whether the observed changes in CoQ10 levels are related to the long-term safety of this drug.
引用
收藏
页码:731 / 739
页数:9
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