Prediction of mechanical behavior of 3D bioprinted tissue-engineered scaffolds using finite element method (FEM) analysis

被引:47
|
作者
Soufivand, Anahita Ahmadi [1 ,2 ]
Abolfathi, Nabiollah [2 ]
Hashemi, Seyyed Ataollah [2 ]
Lee, Sang Jin [1 ]
机构
[1] Wake Forest Sch Med, Wake Forest Inst Regenerat Med, Med Ctr Blvd, Winston Salem, NC 27157 USA
[2] Amirkabir Univ Technol, Biomed Engn Fac, 424 Hafez Ave, Tehran 15916, Tehran Province, Iran
基金
美国国家科学基金会;
关键词
3D printing; CAD/CAM; Finite element method; Scaffold; Tissue engineering; Regenerative medicine; FIBER-DEPOSITED SCAFFOLDS; BONE; ARCHITECTURE; DESIGN; HYDROXYAPATITE; POROSITY; FAILURE;
D O I
10.1016/j.addma.2020.101181
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Three-dimensional (3D) printing can be a promising tool in tissue engineering applications for generating tissue-specific 3D architecture. The 3D printing process, including computer-aided design (CAD), can be combined with the finite element method (FEM) to design and fabricate 3D tissue architecture with designated mechanical properties. In this study, we generated four types of 3D CAD models to print tissue-engineered scaffolds with different inner geometries (lattice, wavy, hexagonal, and shifted microstructures) and analyzed them by FEM to predict their mechanical behaviors. For the validity of computational simulations by FEM, we measured the mechanical properties of the 3D printed scaffolds. Results showed that the theoretical compressive elastic moduli of the designed constructs were 23.3, 56.5, 67.5, and 1.8 MPa, and the experimental compressive elastic moduli were 23.6 +/- 0.6, 45.1 +/- 1.4, 56.7 +/- 1.7, and 1.6 +/- 0.2 MPa for lattice, wavy, hexagonal, and shifted micro-structures, respectively, while maintaining the same construct dimension and porosity. In addition, van der Waals hyperelastic material model was successfully utilized to predict the nonlinear mechanical behavior of the printed scaffolds with different inner geometries. These findings indicated that the CAD-based FEM prediction could be used for designing tissue-specific constructs to mimic the mechanical properties of targeted tissues or organs.
引用
收藏
页数:9
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