The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

被引：562
作者：
Funes, S [1 ]
Hedrick, JA [1 ]
Vassileva, G [1 ]
Markowitz, L [1 ]
Abbondanzo, S [1 ]
Golovko, A [1 ]
Yang, SJ [1 ]
Monsma, FJ [1 ]
Gustafson, EL [1 ]
机构：
[1] Schering Plough Corp, Res Inst, Discovery Technol Dept, Func Genomics Res, Kenilworth, NJ 07033 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 312卷 / 04期
关键词：
GPR54; reproductive function; metastin; KiSS-1; knockout mouse;
D O I：
10.1016/j.bbrc.2003.11.066
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological function of this receptor, we have generated a mutant mouse line with a targeted disruption of the GPR54 receptor (GPR54 -/-). The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features. These data suggest a role for GPR54/KiSS-1 in normal sexual development, and indicate that study of the GPR54 mutant mice may provide valuable insights into human reproductive syndromes. (C) 2003 Elsevier Inc. All rights reserved.
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收藏
页码：1357 / 1363
页数：7
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