AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging

被引：133

作者：

Cordero, Mario D. ^{[1
]}

Williams, Matthew R. ^{[2
]}

Ryffel, Bernhard ^{[3
,4
]}

机构：

[1] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Biomed Res Ctr, Granada 18100, Spain

[2] Hammersmith Hosp, Rob Steiner Unit, London W12 0NN, England

[3] Univ Orleans, Lab Expt & Mol Immunol & Neurogenet INEM, UMR 7355, CNRS, Orleans, France

[4] Univ Cape Town, IDM, Cape Town, South Africa

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2018年 / 29卷 / 01期

关键词：

HIGH-FAT DIET; DRP1-MEDIATED MITOCHONDRIAL FISSION; VASCULAR ENDOTHELIAL-CELLS; BLOOD-BRAIN-BARRIER; THERAPEUTIC TARGET; METABOLIC DISEASES; ALZHEIMERS-DISEASE; MONONUCLEAR-CELLS; INHIBITS NLRP3; LIFE-SPAN;

D O I：

10.1016/j.tem.2017.10.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The NLRP3 inflammasome has recently emerged as an unexpected marker of stress and metabolic risk and has also been implicated in the development of major aging-related diseases such as gout, type 2 diabetes, obesity, cancer, and neurodegenerative and cardiovascular disorders. Several pathways regulating the NLRP3 inflammasome are currently being studied, but how the NLRP3 inflammasome is regulated remains unknown. AMP-activated protein kinase (AMPK), a central regulator of multiple metabolic pathways involved in the pathophysiology of aging and age-related diseases, has emerged as an important integrator of signals controlling inflammation including the inflammasome. In this Opinion article, we show that several AMPK-dependent pathways regulate NLRP3 inflammasome activation during aging, suggesting NLRP3 as a potential pharmacological target in age-related diseases.

引用

页码：8 / 17

页数：10

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