Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship

被引：55

作者：

Thapa, Uttam ^{[2
]}

Thapa, Pritam ^{[2
]}

Karki, Radha ^{[2
]}

Yun, Minho ^{[2
]}

Choi, Jae Hun ^{[2
]}

Jahng, Yurngdong ^{[2
]}

Lee, Eunyoung ^{[1
]}

Jeon, Kyung-Hwa ^{[1
]}

Na, Younghwa ^{[3
]}

Ha, Eun-Mi ^{[3
]}

Cho, Won-Jea ^{[4
]}

Kwon, Youngjoo ^{[1
]}

Lee, Eung-Seok ^{[2
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Div Life & Pharmaceut Sci, Seoul 120750, South Korea

[2] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

[3] Catholic Univ Daegu, Coll Pharm, Kyongsan 712702, South Korea

[4] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 08期

关键词：

Terthiophene; Terpyridine; 4-chromanone; Topoisomerase I and II; Cytotoxicity; 2,4,6-TRISUBSTITUTED PYRIDINE; DNA TOPOISOMERASES; NUCLEASE ACTIVITY; DERIVATIVES; CELLS; COMPLEXES; CHROMENE;

D O I：

10.1016/j.ejmech.2011.04.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Designed and synthesized were a series of 5H-chromeno[4,3-b]pyridines with substitution at 2- and 4-positions with various 5- or 6-membered heteroaromatics as antitumor agents. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Structure activity relationship study showed that 2-furyl or 2-thienyl at 2- or 4-position of central pyridine is crucial in displaying topo I or II inhibitory activity and cytotoxicity. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：3201 / 3209

页数：9

共 31 条

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