Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics

被引：45
作者：
Mukai, Hidefumi [1 ,2 ]
Ogawa, Koki [1 ]
Kato, Naoya [1 ]
Kawakami, Shigeru [1 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pharmaceut Informat, 1-7-1 Sakamoto, Nagasaki 8528588, Japan
[2] RIKEN Ctr Biosyst Dynam Res, Lab Mol Delivery & Imaging Technol, Chuo Ku, 6-7-3 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan
来源：
DRUG METABOLISM AND PHARMACOKINETICS | 2022年 / 44卷
关键词：
Lipid nanoparticle; Nucleic acid; mRNA; Gene editing; Base editing; Ionizable lipid; Targeting; DNA barcode; Recombination; Positron emission tomography; IN-VIVO; TARGETED DELIVERY; MANNOSE RECEPTOR; DRUG; DNA; SIRNA; EXPRESSION; SYSTEM; PET; CRISPR;
D O I：
10.1016/j.dmpk.2022.100450
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based coronavirus disease 2019 vaccines are perfect ex-amples to highlight the role played by drug delivery systems in advancing human health. The funda-mentals of LNPs for the delivery of nucleic acid-and mRNA-based therapeutics, are well established. Thus, future research on LNPs will focus on addressing the following: expanding the scope of drug de-livery to different constituents of the human body, expanding the number of diseases that can be tar -geted, and studying the change in the pharmacokinetics of LNPs under physiological and pathological conditions. This review article provides an overview of recent advances aimed at expanding the appli-cation of LNPs, focusing on the pharmacokinetics and advantages of LNPs. In addition, analytical tech-niques, library construction and screening, rational design, active targeting, and applicability to gene editing therapy have also been discussed.
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页数：13
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