Levels of serum hyaluronic acid, TNF-α and IL-8 in patients with nonalcoholic steatohepatitis

被引:0
作者
Bahcecioglu, IH [1 ]
Yalniz, M
Ataseven, H
Ilhan, N
Ozercan, IH
Seckin, D
Sahin, K
机构
[1] Firat Univ, Tip Fak, Gastroenterol BD, Div Gastroenterol, Elazig, Turkey
[2] Firat Univ, Fac Med, Dept Biochem, Elazig, Turkey
[3] Firat Univ, Fac Med, Dept Pathol, Elazig, Turkey
[4] Fac Vet Sci, Dept Anim Nutr, Elazig, Turkey
关键词
nonalcoholic steatohepatitis; histopathology; hyaluronic acid; interleukin-8; TNF-alpha;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Nonalcoholic steatohepatitis (NASH) is a common cause of liver disease that comprises a wide spectrum of liver damage, ranging from simple steatosis to steatohepatitis. The aim of this study is to investigate serum hyaluronic acid (HA), TNF-alpha, IL-8 levels in patients with non-alcoholic steatohepatitis and to assess their potential value as a noninvasive marker for the severity of histopathology. Methodology: Twenty-eight patients with biopsyproven NASH, 14 patients with cirrhosis and 15 healthy controls were studied. Histopathological findings were graded and staged. HA, IL-8, TNF-levels were determined using by ELISA test Results: Serum HA levels in patients with NASH were significantly higher than in the healthy control group (P < 0.05). However, the levels in patients with cirrhosis were markedly higher than in patients with NASH and healthy controls (P < 0.001). Serum TNF alpha levels were significantly higher in patients with NASH and cirrhosis than in healthy controls (P < 0.05). Serum IL-8 levels in patients with NASH (P < 0.001) and cirrhosis (P < 0.05) were significantly higher than in the healthy control group. There was no correlation between serum HA and IL-8, TNF-alpha, ALT and AST levels. Serum HA level in patients with NASH was 187.26 +/- 139.21 and 143.49 +/- 93.14 in stage in stage 2-3 and in stage 0-1, respectively, but the difference was not significant (P > 0.05). Conclusions: In conclusion, serum HA, IL-8 and TNF-a levels increased in patients with NASH. Their relation with the severity of histopathology is not significant. Serum HA levels may be a useful marker to monitor the conversion from fibrosis to cirrhosis. Further studies are needed on this topic.
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页码:1549 / 1553
页数:5
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