Radiotherapy and Immunotherapy Combinations in Non-small Cell Lung Cancer: A Promising Future?

被引：9

作者：

Hanna, G. G. ^{[1
]}

Illidge, T. ^{[2
]}

机构：

[1] Queens Univ Belfast, Ctr Canc Res & Cell Biol, 95 Lisburn Rd, Belfast BT9 7AE, Antrim, North Ireland

[2] Univ Manchester, Manchester Acad Hlth Sci Ctr, Inst Canc Sci, Manchester Canc Res Ctr,Christie Hosp, Manchester, Lancs, England

来源：

CLINICAL ONCOLOGY | 2016年 / 28卷 / 11期

关键词：

Checkpoint inhibition; immunotherapy; NSCLC; radiotherapy; IMMUNE-RELATED RESPONSE; TUMOR MICROENVIRONMENT; IONIZING-RADIATION; SOLID TUMORS; MELANOMA; MODULATION; MECHANISMS; IPILIMUMAB; RESISTANCE; DOCETAXEL;

D O I：

10.1016/j.clon.2016.07.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The goal of re-programming the host immune system to target malignancy with durable anti-tumour clinical responses has been speculated for decades. In the last decade such speculation has been transformed into reality with unprecedented and durable responses to immune checkpoint inhibitors seen in solid tumours. This mini-review considers the mechanism of action of immune modulating agents and the potential for combination with radiotherapy in the treatment of non-small cell lung cancer. (C) 2016 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

引用

页码：726 / 731

页数：6

共 42 条

[1] The future of anti-CD20 monoclonal antibodies: are we making progress? [J].

Alduaij, Waleed ;

Illidge, Tim M. .

BLOOD, 2011, 117 (11) :2993-3001

[2]

Amin A, 2013, ONCOLOGY-NY, V27, P680

[3] Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities [J].

Antonioli, Luca ;

Yegutkin, Gennady G. ;

Pacher, Pal ;

Blandizzi, Corrado ;

Hasko, Gyorgy .

TRENDS IN CANCER, 2016, 2 (02) :95-109

[4] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[5] The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence [J].

Barker, Holly E. ;

Paget, James T. E. ;

Khan, Aadil A. ;

Harrington, Kevin J. .

NATURE REVIEWS CANCER, 2015, 15 (07) :409-425

[6] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[7] Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer [J].

Brahmer, Julie ;

Reckamp, Karen L. ;

Baas, Paul ;

Crino, Lucio ;

Eberhardt, Wilfried E. E. ;

Poddubskaya, Elena ;

Antonia, Scott ;

Pluzanski, Adam ;

Vokes, Everett E. ;

Holgado, Esther ;

Waterhouse, David ;

Ready, Neal ;

Gainor, Justin ;

Aren Frontera, Osvaldo ;

Havel, Libor ;

Steins, Martin ;

Garassino, Marina C. ;

Aerts, Joachim G. ;

Domine, Manuel ;

Paz-Ares, Luis ;

Reck, Martin ;

Baudelet, Christine ;

Harbison, Christopher T. ;

Lestini, Brian ;

Spigel, David R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (02) :123-135

[8]

Chen YB, 2012, TUMORI, V98, P751, DOI 10.1700/1217.13499

[9] Pseudoprogression and Immune-Related Response in Solid Tumors [J].

Chiou, Victoria L. ;

Burotto, Mauricio .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (31) :3541-+

[10] Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade [J].

Dovedi, Simon J. ;

Adlard, Amy L. ;

Lipowska-Bhalla, Grazyna ;

McKenna, Conor ;

Jones, Sherrie ;

Cheadle, Eleanor J. ;

Stratford, Ian J. ;

Poon, Edmund ;

Morrow, Michelle ;

Stewart, Ross ;

Jones, Hazel ;

Wilkinson, Robert W. ;

Honeychurch, Jamie ;

Illidge, Tim M. .

CANCER RESEARCH, 2014, 74 (19) :5458-5468

← 1 2 3 4 5 →