Using stem cells to study and possibly treat type 1 diabetes

被引：21

作者：

Melton, D. A. ^{[1
]}

机构：

[1] Harvard Univ, Howard Hughes Med Inst, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2011年 / 366卷 / 1575期

关键词：

pancreas; diabetes; stem cells; juvenile diabetes; type; 1; chemical screening; BETA-CELLS; NOD MICE; IN-VIVO; DIFFERENTIATION; MODELS; MOUSE;

D O I：

10.1098/rstb.2011.0019

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cells with the potential to form many different cell types are actively studied for their possible use in cell replacement therapies for several diseases. In addition, the differentiated derivatives of stem cells are being used as reagents to test for drugs that slow or correct disease phenotypes found in several degenerative diseases. This paper explores these approaches in the context of type 1 or juvenile diabetes, pointing to recent successes as well as the technical and theoretical challenges that lie ahead in the path to new treatments and cures.

引用

页码：2307 / 2311

页数：5

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