Fluence rate effects in human glioma spheroids: implications for photodynamic therapy of brain tumors

被引：0

作者：

Madsen, SJ ^{[1
]}

Sun, CH ^{[1
]}

Tromberg, BJ ^{[1
]}

Hirschberg, H ^{[1
]}

机构：

[1] Univ Nevada, Dept Hlth Phys, Las Vegas, NV 89154 USA

来源：

OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY X | 2001年 / 4248卷

关键词：

Photodynamic therapy; 5-aminolevulinic acid; glioma spheroids; brain tumor; fluence rate;

D O I：

10.1117/12.424447

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of fluence rate are investigated in human glioma spheroids incubated in 5-aminolevulinic acid (ALA). It is shown that the response of glioma spheroids to ALA-mediated PDT depends strongly on the rate at which the light dose is delivered. At low doses, lower fluence rates are more effective. For example, at a dose of 50 J/cm(2), near total spheroid kill is observed at fluence rates of as low as 10 mW/cm(2). Below 10 mW/cm(2), however, treatments are not as effective. The fluence rate effect is not as pronounced at higher doses where a favorable response is observed throughout the range of fluence rates investigated The clinical implications of these findings are discussed.

引用

页码：150 / 156

页数：7

共 25 条

[1] EFFECT OF LIGHT FLUENCE RATE ON MAMMALIAN-CELLS PHOTOSENSITIZATION BY CHLOROALUMINIUM PHTHALOCYANINE TETRASULFONATE [J].