Microwave-mediated 'click-chemistry' synthesis of glycoporphyrin derivatives and in vitro photocytotoxicity for application in photodynamic therapy

被引：50
作者：
Garcia, Guillaume [1 ,2 ,3 ]
Naud-Martin, Delphine [1 ,2 ]
Carrez, Daniele [2 ,4 ]
Croisy, Alain [2 ,4 ]
Maillard, Philippe [1 ,2 ,3 ]
机构：
[1] Univ Paris 11, Inst Curie, CNRS, UMR 176, F-91405 Orsay, France
[2] Univ Paris 11, Ctr Univ, Inst Curie, Sect Rech, F-91405 Orsay, France
[3] Univ Toulouse 3, GDR CNRS Med Photoactivables Photochimiotherapie, UMR 5623, F-31062 Toulouse 9, France
[4] Univ Paris 11, INSERM, U749, F-91405 Orsay, France
来源：
TETRAHEDRON | 2011年 / 67卷 / 26期
关键词：
Photodynamic therapy; Porphyrin; Carbohydrate; Click-chemistry; Phototoxicity; Microwave-assisted synthesis; AZIDE-ALKYNE CYCLOADDITION; GLYCOCONJUGATED PORPHYRINS; 1,3-DIPOLAR CYCLOADDITIONS; TERMINAL ALKYNES; CELLS; LIGATION; OXYGEN; TOOL;
D O I：
10.1016/j.tet.2011.04.080
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this paper, we report the synthesis of a series of porphyrins, designed as photodynamic therapy (PDT) agents, substituted by three glycosyl units linked by a triazole group to chromophore in the aim to target tumor cells overexpressing lectin-type membrane receptors, by 'click-chemistry' under microwave heating. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：4924 / 4932
页数：9
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