Mercury contamination of rat amylin mimics vasoactivity and cytotoxic effects

被引：2

作者：

Golpon, HA

Püchner, A

Schmidt, L

Jungclas, H

Barth, P

Welte, T

Wichert, PV

Feddersen, CO

机构：

[1] Univ Marburg, Dept Internal Med, D-35033 Marburg, Germany

[2] Otto Von Guericke Univ, Dept Pulm & Crit Care Med, D-39120 Magdeburg, Germany

[3] Univ Marburg, Dept Clin Nucl Med, D-35033 Marburg, Germany

[4] Univ Marburg, Dept Pathol, D-35033 Marburg, Germany

来源：

PEPTIDES | 2003年 / 24卷 / 08期

关键词：

amylin; mercury; vasoactivity; nitric oxide;

D O I：

10.1016/j.peptides.2003.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rat amylin differs from human amylin (hIAPP) in that it lacks a fibril-forming capacity. As a consequence, toxic effects have been reported for human but not for rat amylin. This report demonstrates how a mercury contamination of commercial rat amylin imitates peptide-related vasoactive and cytotoxic effects on preparations of isolated blood vessels. The source of mercury contamination was believed related to the peptide synthesis. Thiol groups of cysteine-containing peptides are often protected by acetamidomethyl (Acm) which is cleaved by mercuric acetate. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1157 / 1162

页数：6

共 49 条

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