Mercury contamination of rat amylin mimics vasoactivity and cytotoxic effects

被引：2
|
作者：
Golpon, HA
Püchner, A
Schmidt, L
Jungclas, H
Barth, P
Welte, T
Wichert, PV
Feddersen, CO
机构：
[1] Univ Marburg, Dept Internal Med, D-35033 Marburg, Germany
[2] Otto Von Guericke Univ, Dept Pulm & Crit Care Med, D-39120 Magdeburg, Germany
[3] Univ Marburg, Dept Clin Nucl Med, D-35033 Marburg, Germany
[4] Univ Marburg, Dept Pathol, D-35033 Marburg, Germany
来源：
PEPTIDES | 2003年 / 24卷 / 08期
关键词：
amylin; mercury; vasoactivity; nitric oxide;
D O I：
10.1016/j.peptides.2003.07.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rat amylin differs from human amylin (hIAPP) in that it lacks a fibril-forming capacity. As a consequence, toxic effects have been reported for human but not for rat amylin. This report demonstrates how a mercury contamination of commercial rat amylin imitates peptide-related vasoactive and cytotoxic effects on preparations of isolated blood vessels. The source of mercury contamination was believed related to the peptide synthesis. Thiol groups of cysteine-containing peptides are often protected by acetamidomethyl (Acm) which is cleaved by mercuric acetate. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：1157 / 1162
页数：6
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